ADME Profiling Research Scientist (BS/MS)

Novartis Institutes for BioMedical Research is Novartis' global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic era. Over the past four years, Novartis Pharmaceuticals has had the greatest number of new molecular entities approved by the US FDA. With its broad focus on diseases for which there is a need for better medical therapies, and with over 3,000 talented, dedicated research scientists worldwide, Novartis Institutes for BioMedical Research is well-positioned to ensure Novartis maintains its strong pipeline and highly successful track record in new drug discovery. Novartis Institutes has sites in Cambridge, Massachusetts (headquarters); Basel, Switzerland; Horsham, UK; East Hanover, NJ; Vienna, Austria; Tsukuba, Japan and Emeryville, California. Novartis Institutes' Cambridge facilities encompass 950,000 square feet of laboratory and office space. Research in cardiovascular disease, oncology, infectious disease, diabetes, ophthalmology and muscle disease is headquartered in Cambridge. In addition, Cambridge is home to the following platform technologies: Global Discovery Chemistry, Functional Genomics, Developmental & Molecular Pathways, and Models of Disease Center. In order to attract and develop an exceptionally talented and committed staff, Novartis Institutes for BioMedical Research offers an innovative and comprehensive benefits package, including healthcare, insurance, savings, retirement, and work/life benefits. The candidate will be responsible for supporting and optimizing a suite of ADME assays such as PAMPA, Caco-2, metabolic clearance, reversible or time-dependent drug interactions and other transporter assays in Cambridge. The candidate will be dedicated to the daily operation of the existing profiling assays with the agreed throughput, and interpretation of the data. In addition, his/her duty also includes the maintenance/trouble-shooting of a number of automation systems in the lab. The candidate may initiate, lead or participate in the development of new ADME assays. The candidate must have the ability to work interactively on inter-disciplinary teams. The candidate must have excellent communication skills to present at project team meetings, explain the data and offer scientific advice. It will be preferable that the candidate is able to draft scientific proposals and manuscripts/reportsQualificationsBS +5 yrs, or M.S. +2 yrs in drug metabolism/transporter, pharmaceutics, PK/PD, analytical or related fields. Good understanding of underlying principles of cell culturing, in vitro enzymology, PK/PD and analytical chemistry is essential. The candidate must be strong in bioanalysis, lab automation and data management and knowledge of application software in lab automation (Robot, and plate reader) is a plus. Expertise for working with high-throughput in vitro ADME profiling assays is highly preferred. Successful experience in working toward a timeline is favored. Excellent communication (in both oral and written formats) and favorable teamwork skills are a must. Experience in leading technology exploratory projects is desired. Novartis Institutes for BioMedical Research is an equal opportunity employer committed to embracing and leveraging diverse backgrounds. M/F/D/V Job ID: 37449BR