Molecular/in vivo Biology Associate

Novartis Institutes for BioMedical Research is Novartis' global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic era. Over the past four years, Novartis Pharmaceuticals has had the greatest number of new molecular entities approved by the US FDA. With its broad focus on diseases for which there is a need for better medical therapies, and with over 3,000 talented, dedicated research scientists worldwide, Novartis Institutes for BioMedical Research is well-positioned to ensure Novartis maintains its strong pipeline and highly successful track record in new drug discovery. Novartis Institutes has sites in Cambridge, Massachusetts (headquarters); Basel, Switzerland; Horsham, UK; East Hanover, NJ; Vienna, Austria; Tsukuba, Japan and Emeryville, California. Novartis Institutes' Cambridge facilities encompass 950,000 square feet of laboratory and office space. Research in cardiovascular disease, oncology, infectious disease, diabetes, ophthalmology and muscle disease is headquartered in Cambridge. In addition, Cambridge is home to the following platform technologies: Global Discovery Chemistry, Functional Genomics, Developmental & Molecular Pathways, and Models of Disease Center. In order to attract and develop an exceptionally talented and committed staff, Novartis Institutes for BioMedical Research offers an innovative and comprehensive benefits package, including healthcare, insurance, savings, retirement, and work/life benefits. The Developmental and Molecular Pathways (DMP) department is looking for an experienced molecular/in vivo biologist to join an in vivo disease modelling group in the Mouse Models Cambridge (MMC) Unit. MMC is an interdisciplinary group of mouse biologists who create and analyze genetically modified mouse strains and models of disease. The Disease Modelling group creates mouse models of disease with the goal of identifying and validating targets that play a role in human diseases.The successful candidate will be responsible for:- Conducting molecular biology experiments, especially molecular cloning, cell culture and transfection, RNA isolation and Northern, Western, and Southern blotting.- Mouse colony maintenance and model characterization including: Setting up and monitoring breedings, preparation of genomic DNA and PCR genotyping of transgenic mice.- In vivo mouse model development including surgical techniques, delivery of candidate drug regimens, making clinical observations and harvesting samples for molecular and histopathological analysis.-Documentation, analysis and interpretation of experiments. Presentation of results in both written and oral format and delivery of completed reports within a multidisciplinary team environment.QualificationsThe candidate should have a BS/BA or Master s degree in biology or related field, with good animal handling skills and 3-5 years experience. In vivo skills, broad molecular biology expertise, and good data management skills required. Previous demonstration of independence in the conception and design of experiments is highly valued. The candidate must work well in a team setting and have excellent oral and written communication skills. Novartis Institutes for BioMedical Research is an equal opportunity employer committed to embracing and leveraging diverse backgrounds. M/F/D/V Job ID: 38855BR