Oncology Pharmacology PhD- PK/PD

Novartis Institutes for BioMedical Research is Novartis' global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic era. Over the past four years, Novartis Pharmaceuticals has had the greatest number of new molecular entities approved by the US FDA. With its broad focus on diseases for which there is a need for better medical therapies, and with over 3,000 talented, dedicated research scientists worldwide, Novartis Institutes for BioMedical Research is well-positioned to ensure Novartis maintains its strong pipeline and highly successful track record in new drug discovery. Novartis Institutes has sites in Cambridge, Massachusetts (headquarters); Basel, Switzerland; Horsham, UK; East Hanover, NJ; Vienna, Austria; Tsukuba, Japan and Emeryville, California. Novartis Institutes' Cambridge facilities encompass 950,000 square feet of laboratory and office space. Research in cardiovascular disease, oncology, infectious disease, diabetes, ophthalmology and muscle disease is headquartered in Cambridge. In addition, Cambridge is home to the following platform technologies: Global Discovery Chemistry, Functional Genomics, Developmental & Molecular Pathways, and Models of Disease Center. In order to attract and develop an exceptionally talented and committed staff, Novartis Institutes for BioMedical Research offers an innovative and comprehensive benefits package, including healthcare, insurance, savings, retirement, and work/life benefits. The successful candidate will join a dynamic, multi-disciplinary team of scientists in the Oncology in vivo Pharmacology Group, playing a key role in the development of in vivo models of cancer and the use of those models for evaluating new drug candidates. Ideal applicants will possess excellent communication and organizational skills, critical problem-solving abilities, and a commitment to excellence.Candidate will be responsible for: Design, develop, characterize, implement and validate relevant in vivo oncology-related models including subcutaneous, orthotopic and hematological models. Establish innovative pharmaco-dynamic models and tumor models tailored to the molecular target of interest Documentation, analysis and interpretation of experiments for the evaluation of pre-clinical candidates as potential therapeutic agents. Present results both written and verbal and deliver completed reports within a multidisciplinary team environment.Key responsibilities include compound formulation, preliminary safety evaluation, and assessments of efficacy and PK/PD for drug combinations. The candidate will supervise daily activities of a Laboratory with 2-4 associates. He/She will closely collaborate/interact with other Laboratories within the Pharmacology Unit, and with scientists from the Molecular and Cellular Biology Unit, Medicinal Chemistry Unit, and with Clinical Scientists.QualificationsA MS or PhD degree in one of the life sciences, with expertise in in vivo physiology or pharmacology and at least three years postdoctoral and/or industry experience. Industry experience with oncology models is strongly preferred. The candidate should have a comprehensive, in-depth knowledge of Oncology research, particularly related to industrial drug discovery and development, with emphasis on drug combinations. He/she should have a strong background in molecular biology, biochemistry, developmental biology and a good knowledge of statistics. The candidate is also expected to be highly motivated, to have excellent leadership, communication and inter-personal skills. Experience in leading Oncology drug discovery programs and/or supervisory experience is a plus. Novartis Institutes for BioMedical Research is an equal opportunity employer committed to embracing and leveraging diverse backgrounds. M/F/D/V Job ID: 32079BR