Res Inv I, Molecular Discovery

Novartis Institutes for BioMedical Research is Novartis' global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic era.

Over the past four years, Novartis Pharmaceuticals has had the greatest number of new molecular entities approved by the US FDA. With its broad focus on diseases for which there is a need for better medical therapies, and with over 3,000 talented, dedicated research scientists worldwide, Novartis Institutes for BioMedical Research is well-positioned to ensure Novartis maintains its strong pipeline and highly successful track record in new drug discovery.

Novartis Institutes has sites in Cambridge, Massachusetts (headquarters); Basel, Switzerland; Horsham, UK; East Hanover, NJ; Vienna, Austria; Tsukuba, Japan and Emeryville, California. Novartis Institutes' Cambridge facilities encompass 950,000 square feet of laboratory and office space. Research in cardiovascular disease, oncology, infectious disease, diabetes, ophthalmology and muscle disease is headquartered in Cambridge. In addition, Cambridge is home to the following platform technologies: Global Discovery Chemistry, Functional Genomics, Developmental & Molecular Pathways, and Models of Disease Center.

In order to attract and develop an exceptionally talented and committed staff, Novartis Institutes for BioMedical Research offers an innovative and comprehensive benefits package, including healthcare, insurance, savings, retirement, and work/life benefits. Novartis Oncology in Emeryville is seeking a highly motivated scientist to contribute with Protein Biochemistry expertise to the pre-clinical development of targeted oncology therapies. The candidate should have extensive expertise in the area of Protein purification and characterization. The ideal candidate has a Ph.D. in biochemistry or related field, productive post-doctoral work and 3+ years of relevant biopharmaceutical experience with significant experience at the managerial level. The successful candidate will apply these skills to produce proteins for X-ray crystallography, high-throughput screening and therapeutic antibody programs. Candidates should have a proven track record of developing and optimizing protein purification processes. Candidate should have excellent instrument skills including the use of AKTA systems and HPLC. Extensive experience with a wide variety of biochemical methods for protein characterization (protein quantitation, protein modification strategies, cross linking, limited proteolysis) is required. Background in Mass spectrometry and/or expertise using techniques such as surface plasmon resonance, light scattering and fluorescence spectroscopy, is highly desirable. Experience working on X-ray crystallography teams would be a plus. The candidate should have excellent people management skills, the ability to effectively collaborate within multidisciplinary teams, and very good communication skills. This position will have some reporting responsibilities but will substantially contribute and lead from the bench.
Novartis Institutes for BioMedical Research is an equal opportunity employer committed to embracing and leveraging diverse backgrounds. M/F/D/V