Research Scientist/Lab Head- PhD- Biochemistry/Enzymology

Novartis Institutes for BioMedical Research is Novartis' global research organization and is committed to discovering innovative medicines that cure disease and improve human health. By conducting more relevant and predictable drug discovery that can yield new and better medicines for patients, Novartis Institutes for BioMedical Research is redefining drug discovery in the post-genomic era. Over the past four years, Novartis Pharmaceuticals has had the greatest number of new molecular entities approved by the US FDA. With its broad focus on diseases for which there is a need for better medical therapies, and with over 3,000 talented, dedicated research scientists worldwide, Novartis Institutes for BioMedical Research is well-positioned to ensure Novartis maintains its strong pipeline and highly successful track record in new drug discovery. Novartis Institutes has sites in Cambridge, Massachusetts (headquarters); Basel, Switzerland; Horsham, UK; East Hanover, NJ; Vienna, Austria; Tsukuba, Japan and Emeryville, California. Novartis Institutes' Cambridge facilities encompass 950,000 square feet of laboratory and office space. Research in cardiovascular disease, oncology, infectious disease, diabetes, ophthalmology and muscle disease is headquartered in Cambridge. In addition, Cambridge is home to the following platform technologies: Global Discovery Chemistry, Functional Genomics, Developmental & Molecular Pathways, and Models of Disease Center. In order to attract and develop an exceptionally talented and committed staff, Novartis Institutes for BioMedical Research offers an innovative and comprehensive benefits package, including healthcare, insurance, savings, retirement, and work/life benefits. The Cardiovascular and Metabolism Disease area of the Novartis Institutes for Biomedical Research is searching for an individual who will be responsible for running a biochemistry lab focused on drug discovery. Significant expertise in enzymology and assay development is required. Additional experience in using biophysical methodologies and protein production is highly desired. This individuals lab will be responsible for establishing and performing biochemical assays for support of hit-finding activities and support of medicinal chemistry lead optimization. In addition to these activities, the candidate will be expected to perform detailed enzymatic and biophysical mechanistic studies.QualificationsCandidates with experience in assay technologies such as LCMS, fluorescence-based techniques, SPR and/or calorimetry are preferred. This candidate will have to excel in a matrix environment, be highly collaborative, innovative, self-motivated and expected to supervise the daily activities of associate level scientists. A Ph.D. in Chemistry or Biochemistry with a demonstrated record of achievement and with three years or more of drug discovery/pharmaceutical experience is preferred. Novartis Institutes for BioMedical Research is an equal opportunity employer committed to embracing and leveraging diverse backgrounds. M/F/D/V Job ID: 38154BR