Research Scientist--Process Development

Job Category: Biotech/R&D/Science Company: Baxter Healthcare Reference Code: 30135BR Research Scientist--Process Development Baxter International Inc., assists healthcare professionals and their patients with the treatment of complex medical conditions, including cancer, hemophilia, immune disorders, kidney disease and trauma. The company applies its expertise in medical devices, pharmaceuticals and biotechnology to make a meaningful difference in patients' lives. The successful candidate will be responsible for: Developing small-scale purification processes for therapeutic antibodies and proteins; Lead junior members in the purification group to develop various purification processes; Executing studies on the manufacturability, scalability, and robustness of purification process; Design and conduct studies to identify critical scale-up process parameters for purification; Transferring purification processes to cGMP manufacturing, providing training to manufacturing personnel on new processes; Communicating with downstream manufacturing department, conducting investigation and data analyses, trouble-shooting manufacturing purification processes; Communicating with analytical group, performing essential protein assays such as protein concentration determination, SDS-PAGE, size exclusion HPLC to analyze in-process products during purification process development; Maintaining & documenting detailed purification development methods, results; Writing, reviewing, revising, and/or approving purification protocols, purification transfer documents, technical reports; Oral and written presentations & communications to internal manufacturing department or external scientific community. QUALIFICATIONS: The successful candidates must have Bachelor's degree in a biological science field with at least 10 years working experience in biotechnology cGMP working environment, or Master's degree with at least five years industrial experience (Ph.D preferred); have extensive knowledge, expertise and experience in therapeutic antibody or protein purification process development, scale-up and optimization; be very familiar with FDA guidance and requirements for developing a successful therapeutic antibody/protein purification process; be familiar with viral clearance study design and execution. The candidate must be familiar with AKTA purification platform, have extensive experience and expertise in using a variety of chromatography methods/resins to develop purification processes, be very familiar with purification equipment (columns, filters, etc.), software and vendors, be very familiar with various filtration-related processes and products on the market, be very familiar with basic protein characterization methods (protein assays, SDS-PAGE, western blot, HPLC, etc). Candidates must have the ability to work independently, have leadership experience in managing purification projects, have strong trouble-shooting and problem-solving skills, and be able to work well with multi-cross-functional work teams in a fast-pace environment. Excellent written and verbal communication skills are required. As a global leader dedicated to building the best team in health care, Baxter offers competitive compensation and full benefits. To view other opportunities at Baxter, please visit our Careers@Baxter site. EOE M/F/D/V.