Scientist II, Non-Clinical Development

Scientist II, Non-Clinical Development Department/Division: Biotech/R&D/Science Job Type: Full Time, Employee Company: Vertex Pharmaceuticals Inc. Location: US-MA-Boston Job Reference Id: 1173   Description: Posting Title: Scientist II, Non-Clinical Development Department /Division: Drug Metabolism and Pharmacokinetics Classification: Pharmaceutical Research Job Type: Full-time Location: Cambridge Required Travel: None Required Education: Ph.D. Relocation: Yes Job Description Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, inflammation, autoimmune diseases, cancer, pain and bacterial infection. Position Overview: The Scientist II will be responsible to operate and maintain LC/MS instruments and set-up bioanalytical assay methods; validate and write validation reports and also analyze study samples from GLP and cGCP compliant studies to support drug development within DMPK - NCD. In addition, this position is to supervise Associate Scientists in their daily activities, coach and mentor to support GLP compliant studies. Key Responsibilities: Operate and maintain, trouble shoot LC/MS instruments assigned to this group; and set up bioanalytical assay methods using LC/MS complete validation experiments to support toxicology, clinical and other studies; Supervise scientific staff involved in setting up bioanalytical assay methods, validation and study sample analysis; Become fully conversant with GLP regulations and implement all SOPs, Forms and documentation in support of GLP compliant toxicology studies, and cGCP compliant clinical study sample analysis; Collates and interprets complex data systematically and synthesizes results in a cohesive manner to draw conclusions and recommendations to guide project teams in DMPK related drug development activities. Identify and prioritize and introduce relevant emerging technologies to automate the bioanalytical assay methods and data capture and report generation to achieve project team goals in an efficient manner. Presents findings and writes reports to meet target time lines and project goals. Minimum Requirements Minimum M.S. or equivalent degree in Biopharmaceutical Sciences. Minimum 2 years relevant work experience, preferably in the operation and maintenance of LC/MS instrumentation; bioanalytical assay methods development and validation. Proven technical proficiency and demonstrated skills in planning and completing assigned studies within project timelines. Ability to work independently during operation, maintenance of LC/MS instruments and in the design and modifications of assay methods development to achieve rugged and reliable assay methods to support drug development; Good communication skills, both verbal and written within the area of expertise. Good working knowledge of GLP and cGCP regulations and overall drug development process. Ability to work within a team and represent DMPK in project teams to recommend studies and give guidance for drug development. Apply Now