Sr. Research Associate, DMPK

Perform in vitro and in vivo drug metabolism/ pharmacokinetics research to support small molecule drug discovery.

Responsibilities: Design, conduct and analyze in vitro and in vivo DMPK studies to support drug discovery and development projects. Hands-on DMPK skills including bioanalytical methods. Method Development using HPLC and LC/MS/MS. Hands-on animal work with IV or PO administration, blood collection and pre-formulation. Sample preparation using solid/liquid extraction techniques to determine NCE and metabolite levels in biological or assay matrices such as plasma, tissues, etc as well as PK analysis. Previous experience with in vitro screening assays such as CYP inhibition, caco-2, metabolites ID using LC/MS/MS is a plus.

Qualifications: MS with a minimum of 2 years industry experience. Knowledge of DMPK skills including bioanalytical methods using HPLC and LC/MS. Proven problem solving skills and the ability to work effectively within the department and across functions. Ability to interpret bioanalytical/pharmacokinetic findings and write reports.